| Manufacturer | Moderna |
Pfizer-BioNTech |
Janssen |
| Type | mRNA | mRNA | Adenovirus type 26 (Ad26)-vectored |
| Indicated Ages | 18 years and older | 12 years and older | 18 years and older |
| Dose | 0.5 mL | 0.3 mL | 0.5 mL |
| Schedule | 2 doses; 1 month apart | 2 doses; 3 weeks apart | 1 dose |
| Route | Intramuscular | Intramuscular | Intramuscular |
| Appearance | White to off-white suspension may contain white or translucent product-related particulates | White to off-white suspension and may contain white to off-white opaque amorphous particles. | Colorless to slightly yellow, clear to very opalescent. |
| Concentration | 100 mcg of nucleosidemodified messenger RNA (mRNA) encoding the pre-fusion stabilized Spike glycoprotein (S) of SARS-CoV-2 virus | 30 mcg of a nucleoside-modified messenger RNA (modRNA) encoding the viral spike (S) glycoprotein of SARS-CoV-2 | 5×1010 viral particles |
| Preservative | None | None | None |
| Adjuvant | None | None | None |
| Excipients |
|
|
|
| Allergens | (SM-102, polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG], 1.93 mg | 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, 0.05 mg | Polysorbate 80 |
| Media | None | None | PER.C6® TetR Cell Line (no animal components) |
| Diluent | None | (0.9% Sodium Chloride Injection, USP) contributes an additional 2.16 mg sodium chloride per dose | None |
| Packaging | Multiple-dose Vials are supplied as a carton of 10 multiple-dose vials | Multipl-dose Vials (after dilution each vial contains 5 doses of 0.3 mL) | Multiple-dose Vials containing 5 doses (5 mL each) |
| Storage |
• Stored frozen between -25°C to -15°C (-13°F to 5°F). • Do not store on dry ice or below -40ºC (-40ºF). • Vials can be stored refrigerated between 2° to 8°C (36° to 46°F) for up to 30 days prior to first use. • Unpunctured vials may be stored between 8° to 25°C (46° to 77°F) for up to 12 hours. • Do not refreeze once thawed. |
• Prior to dilution, store at -80°C to -60°C (-112°F to -76°F). • After dilution, store the vaccine at 2°C to 25°C (35°F to 77°F). • Discard after 6 hours. |
• The vials should be protected from light. • Unpunctured vials may be stored between 9°C to 25°C (47°F to 77°F) for up to 12 hours. • After the first dose has been withdrawn, the vial should be held between 2° to 8°C (36° to 46°F) for up to 6 hours or at room temperature (maximally 25°C/77°F) for up to 2 hours. • The vial should be discarded if the vaccine is not used within these times. |
| PI date | 12/2020 | 5/2021 | 3/2021 |
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