Components of Varicella and Zoster Vaccines	Excipients Table Allergens Table Components Table
Indication Active immunity against varicella-zoster virus Prevention of herpes zoster (shingles) Proprietary Name Varivax Zostavax Manufacturer Merck Merck Viability Live, attenuated Live, attenuated Microorganism Double-stranded DNA varicella zoster virus, human herpes virus 3, genus Varicella virus Oka/Merck strain Approved Ages 12 months and older 50 years or older Dose 0.5 mL 0.65 mL Route Subcutaneous Subcutaneous Appearance White powder yielding a clear, colorless to pale yellow liquid Semi-hazy to translucent, off-white to pale yellow liquid Concentration (per dose) Oka/Merck varicella virus, ≥ 1350 PFU Oka/Merck varicella virus, ≥ 19,400 PFU Excipients Sucrose, 25 mg Hydrolyzed gelatin, 12.5 mg Sodium chloride, 3.2 mg Monosodium L-glutamate, 0.5 mg Sodium phosphate dibasic, 0.45 mg Potassium phosphate monobasic, 0.08 mg Potassium chloride, 0.08 mg MRC-5 cells, residual components including DNA and protein Trace quantities of: Sodium phosphate monobasic EDTA Neomycin Fetal bovine serum Sucrose, 31.16 mg Hydrolyzed gelatin (porcine), 15.58 mg Sodium chloride, 3.99 mg Monosodium L-glutamate, 0.62 mg Sodium phosphate dibasic, 0.57 mg Potassium phosphate monobasic, 0.10 mg Potassium chloride, 0.10 mg MRC-5 cells, residual components including DNA and protein Trace quantities of: Neomycin Fetal bovine serum Adjuvant None None Allergens Hydrolyzed gelatin, 12.5 mg Neomycin, trace amounts Hydrolyzed gelatin, 15.58 mg Neomycin, trace amounts Preservatives None None Media MRC-5 human diploid-cell culture MRC-5 human diploid-cell culture Packaging Vial, single-dose + 10 vials of diluent 10 single-dose vials + 10 vials diluent Vial, single-dose + 10 vials of diluent 10 single-dose vials + 10 vials diluent Routine Storage -15° C or colder until up to 72 hours before reconstitution, then stored at 2 to 8° C (35-46° F) for up to 72 hours -15° C or colder until up to 72 hours before reconstitution, then stored at 2 to 8° C (35-46° F) for up to 72 hours Package Insert updated August 2011 June 2011 updated January 2012
This page was last updated on January 23, 2012 © 2012 Institute for Vaccine Safety