Issues: Vax Specific

Anthrax

Hepatitis B

Hib

Influenza

Lyme Disease
Meningococcal

MMR    

Polio

Rotavirus

● Smallpox

Tdap/Td

Varicella

Yellow Fever

 

Issues: Misc

Exemptions

Legislation 

New Vax Status

Thimerosal

Independent Vax  Safety Board

 

Vaccine Info

2014 Schedule

ACIP Recs

Components
IOM Reports

● Vax Injury Comp Program
Manufacturer Links

Package Inserts

Reporting AEs

Thimerosal Table

VAERS

VISs

 

Links
 

Search
 

About IVS

Faculty Biographies

Publications

Donations

 

Email IVS

 

Disclaimers & Privacy
 

 

Institute for Vaccine Safety

Johns Hopkins Bloomberg School of Public Health

615 N. Wolfe Street

Room W5041

Baltimore, MD 21205

www.vaccinesafety.edu

 

 

 

 

 

Components of
Tdap Vaccine

Excipients Table
Allergens Table
Components Table

 

Indication

 For active immunization against diphtheria, tetanus, and pertussis 

Proprietary Name

ADACEL

Boostrix

Manufacturer

sanofi pasteur

GlaxoSmitKline

Viability

 

Inactivated

Microorganism

Bordetella pertussis

Corynebacterium diphtheriae

Clostridium tetani

Bordetella pertussis

Corynebacterium diphtheriae

Clostridium tetani

Dose

0.5 mL

0.5 mL

Route

Intramuscular

Intramuscular

Dose form

Suspension

Suspension

Appearance

White, homogenous, cloudy liquid after shaking

Homogeneous, turbid white after shaking

Concentration (per 0.5 mL)

Tetanus toxoid, 5 Lf

Diphtheria toxoid, 2 Lf

Pertussis toxin (detoxified), 2.5 mcg

FHA, 5 mcg

PRN, 3 mcg

Fimbriae types 2 and 3, 5 mcg

Diphtheria Toxoid, 2.5 Lf

Tetanus Toxoid, 5 Lf

Pertactin, 2.5 mcg

FHA, 8 mcg

PT (inactivated), 8 mcg

Preservatives/dose

None

None

Adjuvants/dose

Aluminum phosphate, 1.5 mg

Sodium Chloride, 4.5 mg

Aluminum Adjuvant, 0.39 mg

Excipients

Formaldehyde, ≤ 5 mcg

Glutaraldehyde, <50 ng

2-phenoxyethanol, 3.3 mg

Formaldehyde, ≤100 mcg

Polysorbate 80 (Tween 80), ≤100 mcg

Allergens

 

Stopper vial may contain dry natural latex rubber

Media

 

 

Bordetella pertussis

Stainer-Scholte

Stainer-Scholte liquid

Corynebacterium diphtheria

Mueller's

Fenton medium containing a bovine extract

Clostridium tetani

Mueller-Miller casamino acide

Lantham medium derived from bovine casein

Packaging

Single dose vials

Single Dose vials and prefilled syringes

Routine Storage

2 to 8 C (35-46 F)

Do not freeze

2 to 8 C (35-46 F)

Do not freeze

updated July 2005

 

This page was last updated on February 12, 2014

2014 Institute for Vaccine Safety