Components of

Tdap Vaccines

Components Page
Excipients Table
Allergens Table
       
Name Adacel Boostrix
Manufacturer sanofi pasteur GlaxoSmithKline
Viability Inactivated Inactivated
Indicated Ages 10 - 64 yrs 10 yrs and older
Dose 0.5 mL 0.5 mL
Schedule 1 dose booster 1 dose
Route Intramuscular Intramuscular
Appearance Uniform, white cloudy Homogeneous, turbid white after shaking
Concentration • Tetanus toxoid, 5 Lf
• Diphtheria toxoid, 2 Lf
• Pertussis toxoid (detoxified), 10mcg
• Filamentous hemagglutinin, 5 mcg
• Pertactin, 3mcg
• Fimbriae types 2 and 3, 5 mcg
• Diphtheria toxoid, 2.5 Lf
• Tetanus toxoid, 5 Lf
• Pertussis, 8 mcg
• Filamentous hemagglutinin, 8 mcg
• Pertactin, 2.5 mcg
• Sodium Chloride, 4.4 mg
Preservative None None
Adjuvant Aluminum Phosphate, 1.5 mg Aluminum Hydroxide, ≤0.39 mg
Excipients • 2-Phenoxyethanol, 3.3 mg (0.6% v/v)
• Formaldehyde, ≤5 mcg
• Glutaraldehyde, <50 ng
• Formaldehyde, ≤100 mcg
• Polysorbate 80 (Tween 80), ≤100 mcg
Allergens Tip caps of the prefilled syringes may contain natural rubber latex. Tip caps of the prefilled syringes contain natural rubber latex
Media Clostridium tetani
• Modified Mueller-Miller Casamino acid medium
• Detoxified using formalin
• Purified by Ammonium Sulfate fractionation

Corynebacterium diphtheria
• Modified Mueller’s growth medium
• Purified using Ammonium Sulfate Fractionation
• Detoxified using Formalin

Bordetella pertussis
• Stainer-Scholte medium
• Modified by Casamino Acids and Dimethyl-beta-cyclodextrin
Clostridium tetani
• Modified Lantham medium derived from bovine casein
• Detoxified with formaldehyde, concentrated by ultrafiltration
• Purified by precipitation, dialysis, and sterile filtration

Corynebacterium diphtheria
• Fenton medium containing bovine extract
• Detoxified with formaldehyde, concentrated by ultrafiltration
• Purified by precipitation, dialysis, and sterile filtration

Bordetella pertussis
• Modified Stainer-Scholte liquid medium
• Detoxified using glutaraldehyde and formaldehyde
Packaging • 5-pack single-dose syringes without needles
• 5-pack and 10-pack single-dose vials
• Single and 10-pack single-dose prefilled syringes without needles
• 10-packs single-dose vials
Storage 2-8°C (35-46°F)
Do not freeze
2-8°C (35-46°F)
Do not freeze
PI date March 2014 Oct 2016
    table last updated 10/19/17