Institute for Vaccine Safety - Polio Vaccine Components

Indication	Immunization against polio-virus types 1, 2, and 3
Proprietary Name	IPOL	Orimune (no longer used in US)
Manufacturers	sanofi pasteur	Wyeth-Lederly
Viability	Inactivated	Live, attenuated
Microorganism	Single stranded RNA polio virus genus Enterovirus
Dose	0.5 mL	0.5 mL
Route	Intramuscular or Subcutaneous	Oral
Dose form	Suspension	Suspension
Appearance	Clear and Colorless
Concentration (per 0.5 mL)	Type 1 Poliovirus, 40 D antigen units Type 2 Poliovirus, 8 D antigen units Type 3 Poliovirus, 32D antigen units	Type 1 Poliovirus, 800000 particules Type 2 Poliovirus, 100000 particules Type 3 Poliovirus, 500000 particules
Preservatives	2-phenoxyethanol, 0.5% Formaldehyde, ≤ 0.02%	None
Adjuvants	None
Excipients	Newborn calf serum from bovine spongiform encephalopathy free countries
Allergens	Neomycin,<5 ng Streptomycin, 200 ng or Polymyxin, 25 ng Dry natural latex rubber
Media	Vero cells from monkey kidney cells of Vervet or African green monkeys. Grown in Eagle MEM modified medium. For viral growth the culture medium is replaced by M-199 without calf serum.
Packaging	Prefilled single-dose syringe (1 and 10 packs 10-dose vial	Single dose disposable pipettes (1s, 10s, 50s)
Routine storage	2 to 8° C (35-46° F) Do not freeze	Freeze
*updated July 2005*

This page was last updated on January 23, 2008