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Components of
DTaP Vaccines
Excipients Table
Allergens Table
Components Table

Proprietary Name

Daptacel

Infanrix

Kinrix

Manufacturer

sanofi pasteur

GlaxoSmithKline

GlaxoSmithKline

Viability

Inactivated bacterial vaccine

Inactivated bacterial vaccine Inactivated bacterial vaccine

Indicated Ages

6 wks - 7 yrs

6 wks - 7 yrs 4-6 yrs

Dose

0.5 mL

0.5 mL 0.5 mL

Route

Intramuscular

Intramuscular Intramuscular

Dose form

Suspension

Suspension Suspension

Appearance

White homogeneous cloudy suspension after shaking

Turbid white suspension after shaking Homogeneous, turbid white suspension

Concentration (per 0.5 mL)

Diphtheria, 15 Lf

Tetanus, 5 Lf

PT, 10mcg

Filamentous hemagglutinin, 5 mcg

Pertactin, 3mcg

Fimbriae types 2 and 3, 5 mcg

Diphtheria, 25 Lf

Tetanus, 10 Lf

Pertussis, 25 mcg

Filamentous hemagglutinin, 25 mcg

Pertactin, 8 mcg

Diphtheria, 25 Lf

Tetanus toxoid, 10 Lf

Pertussis toxin, 25 mcg

Filamentous hemagglutinin, 25 mcgPertactin, 8 mcg

Type 1 poliovirus, 40 DU

Type 3 poliovirus, 32 DU

Preservatives/dose

2-Phenoxyethanol, 3.3 mg (0.6% v/v)

None None

Adjuvant

Aluminum Phosphate, 0.33 mg

Aluminum Hydroxide, 0.625 mg Aluminum Hydroxide, 0.6 mg

Excipients

Formaldehyde, 0.1 mg

Glutaraldehyde, 50 ng

Formaldehyde, 100 mcg

Polysorbate 80, 100 mcg

Sodium chloride, 4.5 mg/mL

Formaldehyde, 100 mcg

Polysorbate 80, 100 mcg

Sodium chloride, 4.5 mg

Allergens

Stopper vial may contain dry natural latex rubber

One type prefilled syringe has a tip cap which may contain natural rubber latex and a plunger which does not contain latex.

The other type has a tip cap and a rubber plunger which contain dry naural latex rubber.

The vial stopper does not contain latex.

Neomycin, 0.05 ng

Polymyxin B, 0.01 ng

One type prefilled syringe has a tip cap which may contain natural rubber latex and a plunger whic does not contain latex.

The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

The vial stopper does not contain latex.

Media

Bordetella pertussis

Stainer-Scholte medium

Modified by Casamino Acids and Dimethyl-beta-cyclodextrin

Modified Stainer-Scholte liquid medium

Modified Stainer-Scholte liquid medium

Corynebacterium diphtheria

Modified Muellers growth medium

Purified using Ammonium Sulfate Fractionation

Detoxified using Formalin

Fenton medium containing bovine extract

Detoxified using Formaldehyde

PT detoxified using Glutaraldehyde

FHA and Pertactin detoxified using formaldehyde

Fenton medium containing bovine extract

Clostridium tetani

Mueller-Miller Casamino acid medium

Detoxified using formalin

Purified by Ammonium Sulfate fractionation

Modified Lantham medium derived from bovine casein

Detoxified using Formaldehyde

Modified Lantham medium derived from bovine casein

Packaging

0.5 mL vials

0.5 mL vials and disposable prefilled syringes 0.5 mL vials and disposable prefilled syringes

Routine Storage

2 to 8C (35-46F)

Do not freeze

2 to 8C (35-46F)
Do not freeze
2 to 8C (35-46F)
Do not freeze

PI Last Updated

July 2012

July 2012 July 2012

Table updated Jun 2013

 

 

This page was last updated on February 12, 2014

2014 Institute for Vaccine Safety