Components of

DTaP Vaccines

Components Page
Excipients Table
Allergens Table
       
Name Daptacel Infanrix
Manufacturer sanofi pasteur GlaxoSmithKline
Viability Inactivated bacterial vaccine Inactivated bacterial vaccine
Indicated Ages 6 wks-7 yrs 6 wks-7 yrs
Dose 0.5 mL 0.5 mL
Schedule 5 dose series: 2,4,6 and 15-20 mos, 4-6 yrs 5 dose series: 2,4,6 and 15-20 mos, 4-6 yrs
Route Intramuscular Intramuscular
Appearance White cloudy suspension after shaking Turbid white suspension after shaking
Concentration • Diphtheria, 15 Lf
• Tetanus, 5 Lf
• Pertussis, 10mcg
• Filamentous hemagglutinin, 5 mcg
• Pertactin, 3mcg
• Fimbriae types 2 and 3, 5 mcg
• Diphtheria, 25 Lf
• Tetanus, 10 Lf
• Pertussis, 25 mcg
• Filamentous hemagglutinin, 25 mcg
• Pertactin, 8 mcg
Preservative 2-Phenoxyethanol, 3.3 mg (0.6% v/v) None
Adjuvant Aluminum Phosphate, 0.33 mg Aluminum Hydroxide, 0.625 mg
Excipients • 2-Phenoxyethanol, 3.3 mg (0.6% v/v)
• Formaldehyde, ≤5 mcg
• Glutaraldehyde, 50 ng
• Formaldehyde, ≤100 mcg
• Polysorbate 80, ≤100 mcg
• Sodium chloride, 4.5 mg/mL
Allergens None The tip caps of the prefilled syringes contain natural rubber latex
Media Bordetella pertussis
• Stainer-Scholte medium
• Modified by Casamino Acids and Dimethyl-beta-cyclodextrin

Corynebacterium diphtheria
• Modified Mueller’s growth medium
• Purified using Ammonium Sulfate Fractionation
• Detoxified using Formalin

Clostridium tetani
• Mueller-Miller Casamino acid medium
Detoxified using formalin
• Purified by Ammonium Sulfate fractionation
Bordetella pertussis
• Modified Stainer-Scholte liquid medium

Corynebacterium diphtheria
• Fenton medium containing bovine extract
• Detoxified using Formaldehyde
• PT detoxified using Glutaraldehyde
• FHA and Pertactin detoxified using formaldehyde

Clostridium tetani
• Modified Lantham medium derived from bovine casein
• Detoxified using formaldehyde
Packaging 0.5 mL vials 0.5 mL vials and disposable prefilled syringes
Storage 2-8°C (35-46°F)
Do not freeze
2-8°C (35-46°F)
Do not freeze
PI date Oct 2013 Oct 2016
    table last updated 10/6/17