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Allergens per 0.5 mL
Amphotericin B
RabAvert (Novartis)
Rabies
< 2 ng
Calf Lymph
Dryvax (W)
Smallpox
RabAvert (Novartis)
Rabies
Bovine Serum used in cell culture process
Chicken Protein
Afluria (CSL)
Influenza
trace amounts
Fluarix (GSK)
Influenza
trace amounts
FluLaval (GSK) Influenza trace amounts
Imovax Rabies (sp)
Rabies
trace amounts
YF-Vax (sp)
Yellow Fever
trace amounts
Chlortetracyclin
Dryvax (W)
Smallpox
200 mcg/mL (100/0.5 mL)
RabAvert (Novartis)
Rabies
< 20 ng
Dihydrostreptomycin
Dryvax (W)
Smallpox
200 mcg/mL (100/0.5 mL)
Egg
Attenuvax (Merck)
Measles
residual egg proteins
Fluarix (GSK)
Influenza
residual
FluLaval (GSK)
Influenza
residual (≤1 mcg ovalbumin)
Flumist (MedImmune)
Influenza
Fluvirin (Novartis)
Influenza
residual
Fluzone (sp)
Influenza
residual
MMR II (Merck)
MMR
residual
Mumpsvax (Merck)
Mumps
residual
ProQuad (Merck)
MMR+varicella
residual
YF-Vax (sp) Yellow Fever trace amounts Gelatin (Bovine)
RabAvert (Novartis)
Rabies
<12 mg (Polygeline)
Attenuvax (Merck)
Measles
Hydrolyzed Gelatin, 14.5 mg
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Flumist (MedImmune) Influenza Hydrolyzed Gelatin, 2.00 mg Fluzone (sp)
Influenza
0.05% (added as a stabilizer)
Meruvax II (Merck)
Rubella
Hydrolyzed Gelatin, 14.5 mg
MMR II (Merck)
Measles, Mumps, Rubella
Hydrolyzed Gelatin, 11 mg
Mumpsvax (Merck)
Mumps
Hydrolyzed Gelatin, 14.5 mg
ProQuad (Merck)
MMR+varicella
Hydrolyzed Gelatin, 14.5 mg
Tripedia (sp)
DTaP
residual used in the production of the pertussis concentrate
Varivax (Merck)
Varicella
Hydrolyzed Gelatin, 12.5 mg/dose
YF-Vax (sp)
Yellow Fever
as stabilizer
Zostavax (Merck)
Varicella Zoster
Hydrolyzed gelatin, 15.58 mg
Gentamicin Sulfate
Flumist (MedImmune)
Influenza
<0.015 mcg/mL
Fluarix (GSK)
Influenza
≤0.15 mcg
Latex
ActHIB (AP)
Hib
Diluent vial stopper; vaccine vial contains no rubber
Boostrix (GSK)
Tdap
Cap/Plunger of needleless prefilled syringe contain dry natural latex rubber
Comvax (Merck)
Hib-HepB
Stopper
DAPTACEL (sp)
DTaP
Stopper
DT (AP)
DT
Stopper
Engerix-B (GSK)
Hep B
Cap/Plunger of needleless prefilled syringe contain dry natural latex rubber
Fluarix (GSK)
Influenza
Cap/Plunger of needleless prefilled syringe contain dry natural latex rubber
Havrix (GSK)
Hep A
Cap/Plunger of needleless prefilled syringe contain dry natural latex rubber
HibTITER (Wyeth)
Hib
vial stopper contains dry natural rubber
Infanrix (GSK)
DTaP
Cap/Plunger of needleless prefilled syringe contain dry natural latex rubber
Kinrix (GSK)
DTaP/IPV
Syringe may contain dry natural latex rubber
Menactra (sp)
Meningococcal
Stopper
MENOMUNE (sp)
Meningococcal
Stopper
Pediarix (GSK)
DTaP-HepB-IPV
Cap/Plunger of needleless prefilled Syringe contain dry natural latex rubber
PedvaxHIB (Merck)
Hib
Prevnar (WL)
Pneumococcal
Stopper
Rotarix (GSK)
Rotaviris
Tip cap and Rubber Plunger of applicator
Td (sp)
Td
Stopper, needle cover, plunger
TriHIBit (sp)
DTaP-Hib
Diluent vial stopper; vaccine vial contains no rubber
Tripedia (sp)
DTaP
Stopper
Twinrix (GSK)
Hep AB
Tip cap and plunger of needleless prefilled syringes contain dry natural latex rubber; vial stopper is latex-free
Vaqta (Merck)
Hepatitis A
Stopper
YF-Vax (sp)
Yellow Fever
Stopper
Neomycin
Afluria (CSL)
Influenza
≤0.2 pg
Attenuvax (Merck)
Measles
25 mcg
Dryvax (W)
Smallpox
100 mcg/mL (50 units/0.5 mL)
Fluvirin (Novartis)
Influenza
undetectable amounts
Havrix (GSK)
Hep A
<40 ng/mL (Neomycin sulfate)
Imovax Rabies (sp)
Rabies
<150 mcg (Neomycin Sulfate)
IPOL (sp)
Polio
<5 ng
Kinrix (GSK)
DTaP/IPV
≤0.05 ng
Meruvax II (Merck)
Rubella
25 mcg
MMR II (Merck)
MMR
25 mcg
Mumpsvax (Merck)
Mumps
25 mcg
Pediarix (GSK)
DTaP-HepB-IPV
≤0.05 ng
ProQuad (Merck)
MMR+Varicella
<16 mcg
Varivax (Merck)
Varicella
trace amounts
Zostavax (Merck)
Varicella Zoster
trace amounts
Ovalbumin
Afluria
Influenza
≤ 1 mcg
RabAvert (Novartis)
Rabies
< 3 ug
Fluarix (GSK)
Influenza
≤ 1 mcg
FluLaval (GSK) Influenza ≤1 mcg Polymyxin B
Afluria
Influenza
≤0.03pg
Dryvax (W)
Smallpox
100 units/mL (50 units/0.5 mL)
Fluvirin (Novartis)
Influenza
undetectable amounts
IPOL (sp)
Polio
25 ng
Kinrix (GSK)
DTaP/IPV
≤0.01 ng
Pediarix (GSK)
DTaP-HepB-IPV
≤0.01 ng
Serum, Bovine Fetal
Attenuvax (Merck)
Measles
<1 ppm
IPOL (sp)
Polio
<1 ppm
Meruvax II (Merck)
Rubella
<1 ppm
MMR II (Merck)
MMR
<1 ppm
Mumpsvax (Merck)
Mumps
<1 ppm
ProQuad (Merck)
MMR+varicella
0.5 mcg
RotaTeq (Merck)
Rotavirus
trace amounts
Varivax (Merck)
Varicella
trace amounts
Zostavax (Merck)
Varicella Zoster
trace amounts
Sodium taurodeoxycholate
Afluria (CSL)
Influenza
<10 ppm
Streptomycin
IPOL (sp)
Polio
<200 ng
Thimerosal
DT
DT
25 mcg mercury in multidose; trace amounts in single dose
Engerix-B (GSK)
HepB
<0.5 mcg mercury
Fluarix (GSK)
Influenza
trace amounts; ≤1 mcg mercury
FluLaval (GSK
Influenza
25 mcg mercury
Fluvirin (Novartis)
Influenza
24.5 mcg mercury
Fluzone (sp)
Influenza
none in No Preservative presentations; 25 mcg mercury in 0.5 mL prefilled and multi-dose syringe
MENOMUNE (sp)
Meningococcal
25 mcg mercury in multidose; trace amounts in single dose
Pediarix (GSK)
DtAp-HepB-IPV
trace amounts
TriHIBit (sp)
Hib
trace amounts
Tripedia (SP)
DTaP
trace amounts
Twinrix (GSK)
HepAB
trace amounts
Yeast
Comvax (Merck)
Hib-HepB
"The vaccine contains no detectable yeast DNA, and 1% or less of the protein is of yeast origin."
Engerix-B (GSK)
Hep B
<5%
Gardasil (Merck) HPV "The VLPs are released from the yeast cells by cell disruption and purified by a series of chemical and physical methods." HibTITER (Wyeth) Hib "…yeast extract-based medium that is ultrafiltered before use."
Prevnar (WL)
Pneumococcal
"…and yeast extract-based medium"
Recombivax HB (Merck)
Hep B
<1%
Vivotif Berna (Berna)
Typhoid
yeast extract from media
None
ActHIB (AP)
Hib
Diluent contains latex
ADACEL (ap)
Tdap
DT (sp)
DT
Imogam Rabies (sp)
Rabies IG
OmniHIB (GSK)
Hib
Penumovax 23 (Merck)
Pneumococcal
Typhim VI (sp)
Typhoid
updated November 2008
This page was last updated on March 24, 2009
© 2008 Institute for Vaccine Safety
