DTP and hepatitis B vaccines do not cause sudden infant death syndrome (SIDS). Other vaccines currently routinely recommended to the general population in the U.S.* have not been shown to cause SIDS.
In a 2003 report entitled Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy, the Institute of Medicine (IOM), now called the National Academy of Medicine (NAM), concluded that the evidence favored rejection of a causal relationship between DTP vaccine or exposure to multiple vaccines and SIDS . The 2012 IOM report found no new relevant studies of quality in the literature assessing SIDS and DTaP vaccination . Two large randomized controlled trials found no association between SIDS and pentavalent rotavirus vaccine [3, 4]. No increase in the risk of SIDS after immunization with the DTP vaccine was found among a cohort of 129,834 U.S. children born between 1974 and 1984 . A Vaccine Safety Datalink study of more than 350,000 live births between 1993 and 1998 found no association between hepatitis B birth immunization and neonatal death . A meta-analysis found that immunizations are actually associated with a reduced risk of SIDS; however, this may be attributable to the healthy vaccinee effect . A reanalysis of three case-control studies included in this meta-analysis using the self-controlled case series method found neither an increased nor reduced risk of SIDS during the period after vaccination .
The IOM concluded that there was no mechanistic evidence for an association between SIDS and diphtheria, tetanus or pertussis vaccination, as the publications reviewed provided no evidence beyond a temporal association .
1. Institute of Medicine Immunization Safety Review C. In: Stratton K, Almario DA, Wizemann TM, McCormick MC, eds. Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy. Washington (DC): National Academies Press (US) Copyright 2003 by the National Academy of Sciences. All rights reserved.; 2003.
2. Institute of Medicine. In: Stratton K, Ford A, Rusch E, Clayton EW, eds. Adverse Effects of Vaccines: Evidence and Causality. Washington (DC): National Academies Press (US); 2012.
3. Armah GE, Sow SO, Breiman RF, et al. Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial. Lancet 2010;376:606-14.
4. Goveia MG, Rodriguez ZM, Dallas MJ, et al. Safety and efficacy of the pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy premature infants. The Pediatric infectious disease journal 2007;26:1099-104.